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Madness and memory : the discovery of prions--a new biological principle of disease / Stanley B. Prusiner.

By: Prusiner, Stanley B, 1942- [author.].
Material type: materialTypeLabelBookPublisher: New Haven, Conn. ; London : Yale University Press, c2014Description: xix, 320 pages : illustrations, ports. ; 25 cm.Content type: text Media type: unmediated Carrier type: volumeISBN: 9780300191141 (cloth : alk. paper); 0300191146 (cloth : alk. paper).Subject(s): Prusiner, Stanley B., 1942- | Physicians -- United States -- Biography | Neurologists -- United States -- Biography | Prions -- History | Prion diseases -- History | Physicians -- Autobiography
Contents:
Growing up -- The beginning of an odyssey -- A plethora of theories -- The scrapie race -- Dr. America and the trembling cannibals -- The battle for tenure -- What's in a name? -- Lost in the Pacific fog -- The amyloid story -- Finding the gene -- Jousting with the press -- Deciphering human prion diseases -- What's in a shape? -- Turf battles -- Mad cow and other prion strains -- Stockholm -- The third judgment of Paris -- Epilogue : the quest for therapeutics.
Summary: In 1997, Stanley B. Prusiner received a Nobel Prize, the world's most prestigious award for achievement in physiology or medicine. That he was the sole recipient of the award for the year was entirely appropriate. His struggle to identify the agent responsible for ravaging the brains of animals suffering from scrapie and mad cow disease, and of humans with Creutzfeldt-Jakob disease, had been waged largely alone and in some cases in the face of strenuous disagreement. In this book, Prusiner tells the remarkable story of his discovery of prions - infectious proteins that replicate and cause disease but surprisingly contain no genetic material - and reveals how superb and meticulous science is actually practiced with talented teams of researchers who persevere. He recounts the frustrations and rewards of years of research and offers fascinating portraits of his peers as they raced to discover the causes of fatal brain diseases. Prusiner's hypothesis, once considered heresy, now stands as accepted science and the basis for developing diagnoses and eventual cures. He closes with a meditation on the legacy of his discovery: What will it take to cure Alzheimer's, Parkinson's, Lou Gehrig's and other devastating diseases of the brain?
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Item type Current location Collection Call number Status Date due Barcode
Book Science Museum London
Dana Research Centre Library: Books
Science & Technology Studies Collection 92 PRU PRUSINER (Browse shelf) Available 2402520613

Includes bibliographical references (pages 261-282) and index.

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